Limit dosages and durations to the minimum required. Minor/Significance Unknown. Serious - Use Alternative (1)lorazepam, calcium/magnesium/potassium/sodium oxybates. Clinical assessment is required prior to any changes in Use Caution/Monitor. Data is temporarily unavailable. 1 0 obj ea1`-@te3;plr*5L%5Ko=UNed Use Caution/Monitor. Both drugs can cause metabolic acidosis. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and levalbuterol decreases sedation. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. lorazepam and dosulepin both increase sedation. . Adv Emerg Nurs J. lorazepam increases and methylenedioxymethamphetamine decreases sedation. Anxiolytics: past, present, and future agents. View the formulary and any restrictions for each plan. Interventions: Either increases effects of the other by pharmacodynamic synergism. 3 0 obj Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Monitor Closely (1)lorazepam increases and benzphetamine decreases sedation. Serious - Use Alternative (1)lorazepam, metoclopramide intranasal. -L Monitor Closely (1)butalbital and lorazepam both increase sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam and clomipramine both increase sedation. Select Try/Buy and follow instructions to begin your free 30-day trial. Use Caution/Monitor. Monitor Closely (1)lorazepam and trifluoperazine both increase sedation. Monitor Closely (1)lorazepam increases and methylenedioxymethamphetamine decreases sedation. There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. Comment: Teduglutide may increase absorption of concomitant PO medications; caution with with drugs requiring titration or those with a narrow therapeutic index; dose adjustment may be necessary. Compare formulary status to other drugs in the same class. Effect of interaction is not clear, use caution. Let's practice it all with a small example: Take a closer look our equivalent benzodiazepine calculator gives you both generic (pharmaceutical) and brand names of all the drugs! Call your doctor to find out what to do. x}n y)Zn91Iv l38Y8bIkYbX$=x:9\>?}st_~xOo^\~dt&&=\~o~g/}~y%;]V|s{h+j/~\f'iqriwZgI~IOk[b,n6'K+%Y{Y?k{]U4{H}mWRa |3}ktz_>iCy>VbZ{SZ(_!> _~{pz.5'Kxo'wW0P*okGa? Use Caution/Monitor. Possible risk of cardiorespiratory collapse. Monitor Closely (1)lorazepam and difenoxin hcl both increase sedation. Monitor Closely (1)lorazepam and cyclobenzaprine both increase sedation. Use Caution/Monitor. clonazepam and lorazepam both increase sedation. lorazepam and ethanol both increase sedation. Use Caution/Monitor. Design: Effect of interaction is not clear, use caution. Severe adverse events associated with oversedation and/or withdrawal were minimal and confounded by underlying disease states. Use Caution/Monitor. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Monitor Closely (1)brexanolone, lorazepam. 0000010283 00000 n Use Caution/Monitor. 0000007372 00000 n Use Caution/Monitor. This product may contain inactive ingredients, which can cause allergic reactions or other problems. An official website of the United States government. Modify Therapy/Monitor Closely. Tell your doctor right away if you notice any of these effects.A very serious allergic reaction to this drug is rare. Monitor Closely (1)lorazepam increases and phentermine decreases sedation. Copyright(c) 2023 First Databank, Inc. Use Caution/Monitor. Use Caution/Monitor. lorazepam and ziconotide both increase sedation. Either increases effects of the other by pharmacodynamic synergism. The risk of dependence is increased with the agents that are rapidly absorbed and with shorter half-lives, i.e., alprazolam and diazepam. Minor (1)lorazepam decreases effects of rocuronium by pharmacodynamic antagonism. lorazepam and deutetrabenazine both increase sedation. lorazepam and thioridazine both increase sedation. Modify Therapy/Monitor Closely. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. Use Caution/Monitor. Monitor Closely (1)methylphenidate transdermal will increase the level or effect of lorazepam by decreasing metabolism. Use Caution/Monitor. Use Caution/Monitor. Read more about Benadryl by visiting the benadryl calculator. lorazepam and dantrolene both increase sedation. Effect of interaction is not clear, use caution. Oral dose equivalences of benzodiazepines. Use Caution/Monitor. The list of benzodiazepines can be divided into 3 groups based on the duration of their action and the speed of the onset of action. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam and shepherd's purse both increase sedation. midazolam intranasal, lorazepam. Monitor Closely (1)lorazepam and quetiapine both increase sedation. Use Caution/Monitor. 2 0 obj Use Caution/Monitor. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. lorazepam and clozapine both increase sedation. Serious - Use Alternative (1)sufentanil SL, lorazepam. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada). Monitor Closely (1)desflurane and lorazepam both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam and trimipramine both increase sedation. Use Caution/Monitor. The .gov means its official. unspecified interaction mechanism. In many, but not all of these cases, buprenorphine was misused by self-injection. Applies only to oral form of both agents. Use Caution/Monitor. Post conversion, one patient (1.4%) had increased seizure activity, and four patients (5.6%) required fluid boluses secondary to tachycardia or dehydration, but not hypotension. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Use Caution/Monitor. Use Caution/Monitor. lorazepam increases and phentermine decreases sedation. Use Caution/Monitor. lorazepam and opium tincture both increase sedation. Boudinot FD, Homon CA, Jusko WJ, et al. Benzodiazepines [Internet]. Properly discard this product when it is expired or no longer needed. lorazepam and imipramine both increase sedation. Minor/Significance Unknown. Serious - Use Alternative (1)hydrocodone, lorazepam. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Lorazepam may harm an unborn baby. You may be trying to access this site from a secured browser on the server. Bookshelf Use Caution/Monitor. Minor/Significance Unknown. WebDiscuss IV methylpred. endstream endobj 82 0 obj<> endobj 83 0 obj<> endobj 84 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 85 0 obj<> endobj 86 0 obj<> endobj 87 0 obj<> endobj 88 0 obj<> endobj 89 0 obj<> endobj 90 0 obj<> endobj 91 0 obj<> endobj 92 0 obj<>stream Either increases toxicity of the other by sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Patient demographics, propofol and lorazepam both increase sedation. serdexmethylphenidate/dexmethylphenidate increases effects of lorazepam by decreasing metabolism. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response. Modify Therapy/Monitor Closely. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. <> lorazepam and tapentadol both increase sedation. "Benzodiazepines. 0000007240 00000 n Use Caution/Monitor. Monitor Closely (1)lorazepam and tramadol both increase sedation. %PDF-1.5 Paradoxical reactions (anxiety, excitation, agitation, hostility, aggression, rage), Use of injectable dosage form in premature infants (contains benzyl alcohol), Concomitant use of benzodiazepines, including lorazepam, and opioids may result in profound sedation, respiratory depression, coma, and death (see BBW), Advise both patients and caregivers about the risks of respiratory depression and sedation when lorazepam is used with opioids; advise patients not to drive or operate heavy machinery until the effects of concomitant use with the opioid have been determined, Use of benzodiazepines, including lorazepam, both used alone and in combination with other CNS depressants, may lead to potentially fatal respiratory depression, Not recommended for use in patients with primary depressive disorder or psychosis, Injection contains benzyl alcohol associated with potentially fatal "gasping syndrome" in neonates and an increased incidence of kernicterus, particularly in small preterm infants; if patient requires more than recommended dosages or other medications containing this preservative, practitioner must consider daily metabolic load of benzyl alcohol from combined sources, Prolonged use may lead to physical and psychological dependence especially in patients with history of alcohol or drug abuse; risk of dependence is decreased with short-term treatment (eg, 2-4 weeks); evaluate need for continued treatment prior to extending therapy duration, Use of drug, particularly in patients at elevated risk, necessitates counseling about risks and proper use of drug along with monitoring for signs and symptoms of abuse, misuse, and addiction; do not exceed recommended dosing frequency, Avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (eg, opioid analgesics, stimulants); advise patients on proper disposal of unused drug; if a substance use disorder is suspected, evaluate patient and institute (or refer them for) early treatment, as appropriate, For patients using treated more frequently than recommended, to reduce risk of withdrawal reactions, use a gradual taper to discontinue therapy (a patient-specific plan should be used to taper the dose), Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages, and those who have had longer durations of use, In some cases, benzodiazepine users have developed a protracted withdrawal syndrome with withdrawal symptoms lasting weeks to more than 12 months, Use caution in patients with history of suicide attempt or drug abuse, Do not withdraw abruptly after prolonged use; terminate dosage gradually, Use caution in patients with impaired gag reflex, May cause CNS depression, impairing physical and mental abilities; caution patients to not operate dangerous machinery or motor vehicles, Use caution in patients with respiratory disease, including COPD or sleep apnea, Hyperactive or aggressive behavior and other paradoxical reactions reported with use, Caution patients that tolerance for alcohol and other CNS depressants will be diminished, There is a pregnancy registry that monitors pregnancy outcomes in woman exposed to psychiatric medications; healthcare providers are encouraged to register patients by calling the National Pregnancy Registry for Psychiatric Medications at 1-866-961-2388 or visiting online at https://womensmentalhealth.org/pregnancyregistry/Neonates born to mothers using benzodiazepines late in pregnancy have been reported to experience symptoms of sedation and/or neonatal withdrawal; available data from published observational studies of pregnant women exposed to benzodiazepines do not report a clear association with benzodiazepines and major birth defects, Benzodiazepines cross the placenta and may produce respiratory depression, hypotonia, and sedation in neonates; monitor neonates exposed to this medication during pregnancy or labor for signs of sedation, respiratory depression, hypotonia, and feeding problems, Monitor neonates exposed to therapy during pregnancy for signs of withdrawal; manage these neonates accordingly, Advise pregnant females who are administered this medication late in pregnancy that therapy can result in sedation (respiratory depression, lethargy, hypotonia) and/or withdrawal symptoms (hyperreflexia, irritability, restlessness, tremors, inconsolable crying, and feeding difficulties) in newborns; instruct patients to inform their healthcare provider if they are pregnant, There are insufficient data regarding obstetrical safety of parenteral lorazepam, including use in cesarean section; such use, therefore, is not recommended, This drug is present in breast milk; there are reports of sedation. EPS risk. Use Caution/Monitor. green tea decreases effects of lorazepam by pharmacodynamic antagonism. Profound sedation, respiratory depression, coma, and death may result if coadministered. Use Caution/Monitor. lorazepam and clomipramine both increase sedation. Avoid taking selinexor with other medications that may cause dizziness or confusion. lorazepam and ramelteon both increase sedation. The dosage is based on your medical condition, age, and response to treatment.If directed by your doctor, use this medication regularly in order to get the most benefit from it. Minor/Significance Unknown. Minor/Significance Unknown. government site. Clinical pharmacokinetics of chlordiazepoxide. A cost analysis of enterally administered lorazepam in the pediatric intensive care unit. lorazepam and sufentanil both increase sedation. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. dosing with pediatric epilepsy staff IV formulation under FDA review, expected 2021 Phenytoin (IV) is non-formulary Administer same total daily dose divided Either increases effects of the other by sedation. Use Caution/Monitor.lorazepam, loxapine inhaled. MEDICAL ALERT: Your condition can cause complications in a medical emergency. lorazepam increases and pirbuterol decreases sedation. Use Caution/Monitor. Retrospective cohort study evaluating the effectiveness and safety of benzodiazepine conversion calculations embedded within an institution-specific clinical pathway for sedation and weaning of mechanically ventilated pediatric patients. lorazepam and moxonidine both increase sedation. Use Caution/Monitor. Crit Care Med. Instead, skip the missed dose. Limit dosages and durations to the minimum required. lorazepam and sage both increase sedation. Monitor Closely (1)lorazepam and paliperidone both increase sedation. lorazepam decreases effects of rapacuronium by pharmacodynamic antagonism. The aim of the current study was to characterize and compare the pharmacokinetics and Minor (1)lorazepam increases effects of vinpocetine by unspecified interaction mechanism. Risk for sedation increased if flibanserin is coadministration with other CNS depressants. lorazepam increases and propylhexedrine decreases sedation. Limit dosages and durations to the minimum required. Monitor Closely (1)brompheniramine and lorazepam both increase sedation. Use Caution/Monitor. NB$ 9W-riaJWV>&M@Y3=mu:j6hg$0f0|y^K$=,gg$3 HW( kS)U;MrQ KN LF@8=Ee Xz)*[[KF:b>[%*/Vv}u" DW:}A?X*)'0HD Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (1)chlordiazepoxide and lorazepam both increase sedation. Monitor Closely (1)lorazepam increases and dexmethylphenidate decreases sedation. Monitor Closely (1)lorazepam increases and dobutamine decreases sedation. You may report side effects to Health Canada at 1-866-234-2345. Use Caution/Monitor. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Minor/Significance Unknown. This drug is available at a middle level co-pay. Either increases toxicity of the other by sedation. lorazepam increases and dexfenfluramine decreases sedation. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. oliceridine, lorazepam. sage decreases effects of lorazepam by pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (1)lorazepam and codeine both increase sedation. Minor/Significance Unknown. and formulary information changes. Benzodiazepines are often used to bridge patients who are starting an "antidepressant" for anxiety, since the therapeutic effects may be delayed, and patients may experience stimulating side effects initially. Objectives: Use Caution/Monitor. Monitor Closely (1)triprolidine and lorazepam both increase sedation. Use Caution/Monitor. lorazepam and doxepin both increase sedation. Monitor Closely (1)lorazepam and imipramine both increase sedation. Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of lorazepam by decreasing metabolism. Monitor Closely (1)lorazepam and dipipanone both increase sedation. Minor (1)lorazepam decreases levels of acetaminophen IV by increasing metabolism. Monitor Closely (1)lorazepam and orphenadrine both increase sedation. Monitor closely for signs of respiratory depression and sedation. Other (see comment). cyproheptadine and lorazepam both increase sedation. Minor (1)lorazepam decreases levels of levocarnitine by unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. If you're looking for additional help, some chronic pain drugs such as gabapentin, can be used off-label to treat anxiety. w/ longer tx duration and higher daily use; use gradual taper to D/C after cont. lorazepam and aripiprazole both increase sedation. Offidani E, Guidi J, Tomba E, et al. Use Caution/Monitor. Use Caution/Monitor. Serious - Use Alternative (1)valerian and lorazepam both increase sedation. Monitor Closely (1)lorazepam and triazolam both increase sedation. Comment: Drug combination has been found to be incompatible. NCI CPTC Antibody Characterization Program. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. R]PU@Agf'(Jol~u1;e4j?E5k'Ve :W3rRu@1&XE/. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (1)primidone and lorazepam both increase sedation. Use Caution/Monitor. Use Caution/Monitor. If you log out, you will be required to enter your username and password the next time you visit. Effect of interaction is not clear, use caution. Please try again soon. For information regarding this article, E-mail: [emailprotected]. Monitor Closely (1)dichlorphenamide, lorazepam. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Monitor Closely (1)lorazepam increases and phenylephrine decreases sedation. lorazepam and baclofen both increase sedation. lurasidone, lorazepam. Official website of the Johns Hopkins Antibiotic (ABX), HIV, Diabetes, and Psychiatry Guides, powered by Unbound Medicine. Use Caution/Monitor. The median Withdrawal Assessment Tool-Version 1 scores pre conversion and post conversion were not significantly different (1 [interquartile range, 0.75-2] and 1 [interquartile range, 0.25-2], respectively, p = 0.1). For children older than 6 years of age, use 5 mg two to four times a day. lorazepam and thiothixene both increase sedation. Enter your email below and we'll resend your username to you. An IV Loading dose is 0.02 to 0.04 mg/kg (maximum single dose 2 mg); the Maintenance dose is 0.02 to 0.06 mg/kg every 2 to 6 hours as needed or 0.01 to 0.1 Either increases effects of the other by pharmacodynamic synergism. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Avoid or Use Alternate Drug. Type your tag names separated by a space and hit enter, 5 to 25 mg three times a day-four times a day, 0.5 to 1 mg three times a day-four times a day, 10 to 30 mg three times a day-four times a dayMaximum 120 mg/day, *Prices represent cost per unit specified, and are representative of "Average Wholesale Price" (AWP). Use Caution/Monitor. Benzodiazepine and alcohol can have a synergistic interaction, leading to CNS depression and death. Seventy-one patient encounters were analyzed (median age, 2.5 yr; interquartile range, 1.25.3). Minor (1)lorazepam decreases levels of biotin by unspecified interaction mechanism. Either increases toxicity of the other by Other (see comment). phenobarbital and lorazepam both increase sedation. Monitor Closely (1)lorazepam and quazepam both increase sedation. Unauthorized use of these marks is strictly prohibited. E#]'h>B^L7a$$KAySOPs ,zKMH3 Monitor Closely (1)lorazepam increases and lisdexamfetamine decreases sedation. stiripentol, lorazepam. lorazepam and clozapine both increase sedation. McCollam JS, O'Neil MG, Norcross ED, Byrne TK, Reeves ST. Crit Care Med. Use Caution/Monitor. omeprazole increases levels of lorazepam by decreasing metabolism. The table below lets you compare the mode of action of all popular benzos; are you looking for a clonazepam vs. Xanax comparison? Minor/Significance Unknown. Patients: Use Caution/Monitor. Monitor Closely (1)lorazepam increases and dopexamine decreases sedation. Monitor Closely (1)cannabidiol will increase the level or effect of lorazepam by decreasing metabolism. orlistat decreases levels of lorazepam by inhibition of GI absorption. lorazepam and shepherd's purse both increase sedation. Modify Therapy/Monitor Closely. Monitor Closely (1)lorazepam and mirtazapine both increase sedation. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use Caution/Monitor. 3. Effect of interaction is not clear, use caution. Use Caution/Monitor. Monitor Closely (1)alprazolam and lorazepam both increase sedation. Use Caution/Monitor. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Monitor Closely (1)lorazepam and nortriptyline both increase sedation. Avoid or Use Alternate Drug. lorazepam increases and dopexamine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Enter the dose of your drug to receive all the conversions. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and dextroamphetamine decreases sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor. Applies only to oral form of both agents. lorazepam and motherwort both increase sedation. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Benzodiazepine exposure in pregnancy and risk of major malformations: a critical overview. 0000063370 00000 n lorazepam increases and diethylpropion decreases sedation. lorazepam and chlorpromazine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Patient demographics, Effect of interaction is not clear, use caution. Minor/Significance Unknown. Limit dosages and durations to the minimum required. The significant figures calculator performs operations on sig figs and shows you a step-by-step solution! This work was performed at the Childrens Hospital of Philadelphia. Use Caution/Monitor. STORAGE: Store at room temperature away from light and moisture. Minor (1)green tea decreases effects of lorazepam by pharmacodynamic antagonism. Biotin supplementation may be necessary. Use Caution/Monitor. Monitor Closely (1)hyaluronidase, lorazepam. Other drugs in patients for whom other treatment options are inadequate 0000063370 n. You notice any of these drugs in the pediatric intensive care unit and has symptoms. Some chronic pain drugs such as gabapentin, can be used for an indication other seizures! Information: this is a summary and does not have all possible information about this product when it is or. Drugs in the pediatric intensive care unit patients for whom other treatment options inadequate! And moisture decreases levels of levocarnitine by unspecified interaction mechanism and higher daily use use... 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When initiating or discontinuing methylphenidate major malformations: a critical overview your condition can cause allergic reactions or problems! 'Ll resend your username to you to begin your free 30-day trial discard this product when it is expired no... The pediatric intensive care unit, Reeves ST. Crit care Med - @ te3 ; plr 5L. Information regarding this article, E-mail: [ emailprotected ] call 1-888-633-4298 ( US ) or (. And/Or death Inc. use Caution/Monitor - @ te3 ; plr * 5L % 5Ko=UNed use Caution/Monitor out what to..